Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins
نویسندگان
چکیده
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
متن کاملIdentifying Unfolding Pathways of G Protein-Coupled Receptor Protein Structures
G protein-coupled receptors (GPCRs) have important functionality in cell signaling processes by external affects such as light, smell, taste, and hormones. The conformational changes in structures of GPCR’s play vital role in signaling processes. The understanding of conformational changes is useful to determine basis of certain diseases that are related to malfunctioning of these proteins. The...
متن کاملA Role for G-Proteins in Directing G-Protein-Coupled Receptor–Caveolae Localization
Caveolae are membrane domains that may influence cell signaling by sequestering specific proteins such as G-protein-coupled receptors (GPCRs). While previous reports largely show that Gα(q) subunits, but not other G-proteins, interact strongly with the caveolae protein, Caveolin-1 (Cav1), the inclusion of GPCRs in caveolae is controversial. Here, we have used fluorescence methods to determine t...
متن کاملG protein-coupled receptor rhodopsin.
The rhodopsin crystal structure provides a structural basis for understanding the function of this and other G protein-coupled receptors (GPCRs). The major structural motifs observed for rhodopsin are expected to carry over to other GPCRs, and the mechanism of transformation of the receptor from inactive to active forms is thus likely conserved. Moreover, the high expression level of rhodopsin ...
متن کاملG-Protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2015
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2015.07.007